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In economic theory, physical capital is one of the three primary factors of production, also known as inputs in the production function.

The others are natural resources (including land), and labor — the stock of competences embodied in the labor force.

It should be noted that not all medical procedures that introduce alterations to a patient's genetic makeup can be considered gene therapy.

The first attempt at modifying human DNA was performed in 1980 by Martin Cline, but the first successful and approved nuclear gene transfer in humans was performed in May 1989.

The first therapeutic use of gene transfer as well as the first direct insertion of human DNA into the nuclear genome was performed by French Anderson in a trial starting in September 1990.

Bone marrow transplantation and organ transplants in general have been found to introduce foreign DNA into patients.

Gene therapy is defined by the precision of the procedure and the intention of direct therapeutic effects.

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